Product Specifications:

Appearance:- Off-white to light yellow powder

Specific optical rotation:- +68.0° ±3° (c=1.0, in Methanol)

Melting point:- 248±5 °C

Water:- NMT0.5%

Identification:- HPLC IR

Heavy metals:- NMT 10ppm

Residue on ignition:-  NMT0.1%

Related substances:-

·        Desfluoro aprepitant:-  NMT 0.15%

·        R,R,R-Diastereomer:-NMT 0.15%

·        Any other individual impurity:- NMT 0.10%

·        Total impurities: NMT 0.50%

Enantiomer purity:-  NMT 0.15% of the S,R,S-enantiomer

Assay:- NLT 98.0% and NMT 102.0% (on the anhydrous basis)

Organic volatile impurities:- Methanol NMT 2500 ppm; Xylene NMT 2170 ppm; Toluene NMT 890 ppm; DMSO NMT 5000ppm